Gluten Related Neurological Disorders and Ataxia 

About Gluten Related Neurological Disorders and Ataxia

Gluten-related neurological diseases (GRND) are a spectrum of immune-mediated disorders triggered by the ingestion of gluten. Coeliac disease (CD) is the best characterised of these with a prevalence of 1% in the UK. However, two thirds of gluten-sensitive patients with neurological manifestations do not have classic digestive symptoms or enteropathy (coeliac disease) yet respond to a gluten-free diet.

The NIHR Sheffield Biomedical Research Centre will work to evaluate new biomarkers in the diagnosis of neurological dysfunction due to gluten sensitivity. In particular the role of an enzyme called transglutaminase-6 (TG6) will be explored as a biomarker and its role in the pathophysiology of GRND investigated. 

The commercial development of a TG6 antibody will be pursued as a tool to screen for gluten-sensitivity. Working with the Imaging & Engineering theme, the use of novel non-invasive Magnetic Resonance (MR) spectroscopy as a biomarker and monitoring tool in the treatment of gluten and other ataxias will also be developed.

The Sheffield Ataxia Centre is one of only three National Ataxia centres in the UK. It has been accredited by Ataxia UK as an Ataxia Centre of Excellence in 2007. It cares for over 1700 patients with various types of ataxias. There is particular emphasis on immune ataxias and in particular Gluten Ataxia, originally described in Sheffield in 1996.


Visit Professor Marios Hadjivassiliou's webpage on the NHS Website

Professor Marios Hadjivassiliou

Gluten Related Neurological Disorders and Ataxia Sub Theme Lead

Visit Professor David Sander's webpage on the University of Sheffield Website

Prof. David Sanders

Dr. Channa Hewamadduma

Sheffield BRC > Research themes > Neuroscience > Gluten Related Neurological Disorders and Ataxia