An exciting opportunity has arisen for an MND Project Manager based within the NIHR Biomedical Research Centre.

This full time, fixed term 18-month role will support EXPERTS-ALS, a ground-breaking project that provides a platform to test drugs rapidly for their potential to slow the progression of Amyotrophic Lateral Sclerosis (ALS, the commonest form of Motor Neuron Disease (MND)) in people living with ALS.

Main duties of the job

The post holder will provide key project management for the EXPERTS-ALS Programme with a specific focus on research capacity development (WS3) and the pipelines of investigational medicinal products prioritised for use in the platform (WS1).

Developing the next generation of researchers is a fundamental part of research capacity development in EXPERTS-ALS. Our funded early career researchers (ECRs) support the study, but we have made it our mission to ensure that those working on EXPERTS-ALS have access to opportunities beyond that of their day-to-day research.

The post holder will take a lead role in working with investigators and CTRUs to support the pipeline of IMPs entering the platform. This role will support the delivery of a continuous pipeline of drugs for the platform trial using the best available evidence from pre-clinical models and a wide range of data resources, including genomics, AI drug discovery programs and evidence from other neurodegenerative diseases.

The primary goal of this is to select the most appropriate compounds for prioritisation in EXPERTS-ALS, based on disease relevance, safety profile and central nervous system penetration. Furthermore, data from ECR projects delivered WS3 in response to drugs can be fed back to preclinical modelling in WS1 to identify new, or refine existing, pathways of disease relevance, and ultimately those which best predict a positive outcome in Phase III trials.

Grade: NHS AfC Band 7

Contract: Fixed Term 18 months from start date (All existing NHS staff will only be considered on a secondment basis.)

Working Pattern: Full-time
Location: Royal Hallamshire Hospital, Sheffield

For more information and to apply, please visit the following - BRC MND Project Manager - Job Advert

Closing date: 11th October 2026

If you would like any further information, please contact Luke Barron, NIHR BRC Operations Manager, luke.barron@nhs.net.

Job Advert

EXPERTS-ALS Website

The NIHR funds, enables and delivers world-leading health and social care research that improves people's health and wellbeing and promotes economic growth.

NIHR Biomedical Research Centres (BRCs) are collaborations between NHS organisations and universities. They bring together academics and clinicians to translate scientific discoveries into potential new treatments, diagnostics and technologies.