Coronary Artery Disease

About Coronary Artery Disease

Coronary artery disease (CAD) is a prevalent cardiovascular disease in the UK. It is a condition where the oxygen supply of the heart is interrupted by a blockage in the coronary arteries. The walls of these arteries can accumulate fatty deposits in a process called atherosclerosis and these deposits can reduce or completely stop the flow of blood through these vessels. There are multiple risk factors for CAD, one of which is diabetes, a key research theme of the NIHR Sheffield BRC.

Our aims

Over the next 5 years, we aim to:

  • Establish individualised and targeted pharmacological strategies to improve clinical outcomes and extend life expectancy in people with CAD

  • Use virtual coronary physiology to provide cost-effective and widely applicable personalised management of CAD patients

  • Develop software for the automated virtual assessment of coronary physiological parameters in order to guide the management of patients undergoing invasive coronary angiography

  • Demonstrate the advantages of novel antithrombotic regimens in patients with CAD

Our research outputs will support phase 3 studies of novel antithrombotic regimens in patients with diabetes, with or without proven CAD, and the impact of virtual (computed) coronary physiology upon decision-making in the management of CAD patients.


Professor Simon Heller

Coronary Artery Disease Sub Theme Co-Lead

Professor Julian Gunn

Coronary Artery Disease Sub Theme Co-Lead

Prof. Solomon Tesfaye

Prof. Jim Wild

Prof. Timothy Chico

Prof. Steven Sourbron

Prof. Ian Sabroe

Prof. Steve Goodacre

Dr. Andrew Swift

Dr Paul Morris

Dr. Justin Lee

Dr Ahmed Iqbal

Dr William Parker

Dr Rebecca Gosling

Dr. Thomas Nelson